Our Google Scholar profile can be found here

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Our page on the UCL Chemistry Department site  can be found here

           

2022

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K. Nyandoro, C. M. G. Lamb, H. Yu, J. Shi, and D Macmillan. “Investigation of acyl transfer auxiliary-assisted glycoconjugation for glycoprotein semi-synthesis. Org.  Biomol. Chem.  2022 20, 8506-8514.

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C. M. G. Lamb, J. Shi, J.D. Wilden and D. Macmillan  "Novel electrochemically-mediated peptide dethiylation in processes relevant to native chemical ligation". Org. Biomol. Chem. 2022, 20, 7343-7350.

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2021

 

N. G. Barnes, K. Nyandoro, H. Jin, D. Macmillan.  “Rapid access to Asp/Glu sidechain hydrazides as thioester precursors for peptide cyclization and glycosylation”. Chem. Commun.  2021, 57, 1006-1009.

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2018

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G. Hogarth, D. Macmillan, C.J. Richard. “Microwave-assisted synthesis of cyclopentadienone iron tricarbonyl complexes: Molecular structures of [{η4-C4R2C(O)C4H8}Fe(CO)3] (R = Ph, 2,4-F2C6H3, 4-MeOC6H4) and attempts to prepare Fe(II) hydroxycyclopentadienyl-hydride complexes.” Transition Met. Chem. 2018, 43, 421-430.

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S.M. Gibson, D. Macmillan, T.D. Sheppard. “Synthesis of Protected Boronocysteine”. Synlett, 2018; 29(03): 314-317,

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2017

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D.J. Castillo-Pazos, D. Macmillan. "Investigation of cysteine as an activator of sidechain N→S acyl transfer and tail-to-sidechain cyclization". Synlett, 2017, 28, 1923-1928..

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D. Macmillan. "Going Round in circles with N→S acyl transfer". Synlett, 2017, 28 (13), 1517-1529.

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Y. Zhu, J. Underwood, D. Macmillan, L. Shariff, R. O’Shaughnessy, J.I. Harper, E. Heally, and W-L. Di.  “Persisitent kallikrein5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity.” J. Aller. Clin. Immunol. 2017, 40(5), 1310-22.e5.

 

2016

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Chen, W., Kinsler, V. A., Macmillan, D., & Di, W. L. (2016). Tissue kallikrein inhibitors based on the sunflower trypsin inhibitor scaffold - A potential therapeutic intervention for skin diseases. PLoS ONE, 11 (11). doi:10.1371/journal.pone.0166268

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2015

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B. Cowper, L. Shariff, W. Chen, S. M. Gibson, W.-L. Di and D. Macmillan.  Expanding the scope of N→S acyl transfer in native peptide sequences.  Org. Biomol. Chem. 2015, 13, 7469-7476.

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B. Cowper, T. M. Sze, B. Premdjee, A. F. Bongat White, A. Hacking and D. Macmillan.  Examination of mercaptobenzyl sulfonates as novel catalysts for native chemical ligation: Application to the assembly of Glycosylated Glucagon-Like Peptide 1 (GLP-1). Chem. Commun, 2015, 51, 3208-3210.

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2014

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L. Shariff, Y. Zhu, B. Cowper, W.-L. Di, D. Macmillan.  Sunflower trypsin inhibitor (SFTI-1) analogues of synthetic and biological origin via N→S acyl transfer: potential inhibitors of human Kallikrein-5 (KLK5). Tetrahedron (symposium in print), 2014, 70(42): 7675-7680.

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2013

 

Adams, A.; Cowper, B.; Morgan, R.E.; Premdjee, B.; Caddick, S.; Macmillan, D.  Cysteine Promoted C-Terminal Hydrazinolysis of Native Peptides and Proteins. Angew. Chem. Int. Ed. 3013, 52, 13062-13066.

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Currie, S.M.; Findlay, E. G.; McHugh, B.; Mackellar, A.; Man, T.; Macmillan, D.; Wang, H.; Fitch, P.; Schwarze, J.; Davidson, D.J. The human cathelicidin LL-37 has antiviral activity against Respiratory Syncytial Virus. PLoS ONE, 2013, 8, e73659.

 

Cowper, B.; Craik, D.; Macmillan, D.  Making Ends Meet: Chemically Mediated Circularization of Recombinant Proteins. Chembiochem, 2013, 14(7): 809-812.

 

Adams, A.L.; Macmillan, D.  Investigation of Peptide Thioester Formation via N-Se Acyl Transfer.  J. Peptide Sci. 2013, 19(2): 65-73.

 

2012

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Harvey, S.; Porrini, M.; Stachl, C.; Macmillan, D.; Zinzalla, G.; Barran, P.  Small Molecule Inhibition of c-MYC:MAX leucine zipper for-mation is revealed by Ion Mobility Mass Spectrometry.  J. Am. Chem. Soc. 2012, 134(47): 19384-19392.

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Jungmichel, S.; Clapperton, J.A.; Lloyd, J.; Spycher, C.; Pavic, L.; Li, J.; Haire, L.F.; Bonalli, M.; Lukas, C.; Lukas, J.; MacMillan, D.; Stucki, M.; Smerdon, S.J. The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.  Nucleic Acids Res.  2012, 40 (9). 3913–3928.

 

2011

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K. Hirano, M. Izumi, D. Macmillan, K. Tezuka, T. Tsuji, Y. Kajihara.  Semisynthesis of Erythropoietin Analogue Having Three Oligosaccharides. J. Carbohydrate. Chem. 2011, 306-319.

 

Y. Kajihara, M. Izumi, K. Hirano, T. Murase, D. Macmillan, R. Okamoto.  Elucidating the Function of Complex-Type Oligosaccharides by Use of Chemical Synthesis of Homogeneous Glycoproteins.  Isr. J. Chem. (special issue on Chemical Protein Synthesis), 2011, 51, 917-929.

 

D. Macmillan, A. Adams, B. Premdjee.  Shifting native chemical ligation into reverse through N-S acyl transfer.   Isr. J. Chem. (special issue on Chemical protein Synthesis), 2011, 51, 885-899.

 

B. Premdjee, A. L. Adams, D. Macmillan.  Native N-glycopeptide thioester synthesis through N-S acyl transfer, Bioorg. Med. Chem. Lett. 2011, 21, 4973-4975.

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D. Macmillan, M. De Cecco, N. L. Reynolds, L. F. A. Santos, P. E. Barran, J. R. Dorin.  Synthesis of Cyclic Peptides through an Intramolecular Amide Bond Rearrangement, Chembiochem, 2011, 12, 2133-2136.

 

Richardson, J.P.; Macmillan, D.  Semi-Synthesis of glycoproteins from E. coli through native chemical ligation. Meth. Mol. Biol. 2011, 705, 151-174.

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2010

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Masania, J.; Li, J.; Smerdon, S.J. and Macmillan, D.  Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer.  Org. Biomol. Chem. 2010, 8, 5113-5119.

 

Ackrill, T.; Anderson, D. W.; Macmillan D.Towards biomolecular assembly employing Extended Native Chemical Ligation in combination with thioester synthesis using an N→S acyl shift. Protein Science-Biopolymers, 2010, 94(4), 495-503.

 

Kang, J.; Macmillan D. Protein thioester synthesis via an N-S acyl shift. Org. Biomol. Chem. 2010, 8, 1993-2002..

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De Cecco, M.; Seo, E.S.; Clarke, D.J.; McCullough, B.J.; Taylor, K.; Macmillan, D.; Dorin, J.R.; Campopiano, D.J.; and Barran, P.E. Conformational preferences of linear b-defensins are Revealed by Ion Mobility-Mass Spectrometry. J. Phys Chem. B, 2010, 114(6), 2312-2318.

 

B. J. McCullough, J. M. Kalapothakis, W. Chin, K. Taylor, D. J. Clarke, H. Eastwood, D. Campopiano, D. MacMillan, J. Dorin, P. E. Barran, Binding a Heparin Derived Disaccharide to Defensin Inspired Peptides: Insights to Antimicrobial Inhibition from Gas Phase Measurements.  Phys. Chem. Chem. Phys. 2010, 12, 3589-3596.

 

Tyrrell, C., De Cecco, M., Reynolds, N. L., Kilanowski, F., Campopiano, D., Barran, P., Macmillan, D. and Dorin, J.R.  Isoleucine/leucine2 is essential for chemoattractant activity of β-defensin Defb14 through chemokine receptor 6. Mol. Immunol. 2010, 47, 1378-1382.

 

Richardson, J.P.; Chan, C-H.; Blanc, J.; Saadi, M.; Macmillan D. Towards semi-synthetic glycoprotein mimics:  Widening the application of peptide thioester synthesis employing N-S acyl transfer. 2010, Org. Biomol. Chem. 8, 1351-1360.

 

Tyrrell, C., De Cecco, M., Reynolds, N. L., Kilanowski, F., Campopiano, D., Barran, P., Macmillan, D. and Dorin, J.R.  Peptide Fragments of a ß-Defensin Derivative With Potent Bactericidal Activity.  Antimicrob. Agents Chemother. 2010, 54(5), 1922-1929.

 

Virdee, S.; Macmillan, D.; Waksman, G.  Semisynthetic Src SH2 Domains Demonstrate Altered Phosphopeptide Specifity by Incorporation of Unnatural Amino Acids. Chem. Biol. 2010, 17, 274-284.

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2009

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Kang, J.; Reynolds, N.L.; Tyrrell, C.; Dorin, J.R.; and Macmillan, D.  Peptide thioester synthesis through N-S acyl-transfer:  Application to the synthesis of a b-Defensin. Org. Biomol. Chem. 2009, 7, 4918-4923.

 

Hirano, K.; Macmillan, D.; Tezuka, K.; Tsuji, T.; Kajihara, Y.  Design and synthesis of a homogeneous erythropoietin analogue having two human complex type sialyloligosaccharides by combined use of chemical and bacterial protein expression methods. Angew. Chem. Int. Ed. 2009, 48, 9557-9560.

 

Taylor, K.; Rolfe, M.; Kilanowski, F.; Pathania, U.; Reynolds, N.; Clarke, D.; Yang, D.; Oppenheim, J.; Samuel, K.; Howie, S.; Barran, P.; MacMillan, D.; Campopiano, D.; Dorin, J. Defr1 is allelic to Defb8 and is chemoattractant for dendritic cells and CD4 T cells but does not act through chemokine receptor 6. Eur. J. Immunol. 2009, 39(5) 1353-1360.

 

Macmillan, D.  2, 3, 4-Trimethoxy-6-[[(4-methoxyphenyl)methyl]thio] benzaldehyde, eEROS, , DOI: 10.1002/047084289X.rn00970.

      (http://www.mrw.interscience.wiley.com/eros/articles/rn00970/sect0-fs.html)

 

Kang, J.; Richardson, J.P.; Macmillan, D. 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters, Chem. Commun. 2009 (4), 407-409.

 

2008

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Richardson, J.P.; Macmillan, D.  Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation. Org. Biomol. Chem. 2008, 6, 3977-3982.

 

Marchesan, S.; Macmillan D.  Chemoenzymatic Synthesis of GDP-Azidodeoxymannoses: Probes for Mannosyltransferase Activity. Chem. Commun. 2008, 4321 – 4323.

 

Li, J.; Taylor, I.A.; Lloyd, J.; Clapperton, J.A. Howell, S.; Macmillan, D.; Smerdon, S.J.Chk2 Oligomerisation Studied by Phosphopeptide Ligation: Implications for Regulation and Phosphodependant Interactions. J. Biol. Chem. 2008, 283 (51) 36019-36030.

 

McCullough, B.; Kalapothakis, J.; Eastwood, H.; Kemper, P.; Macmillan, D.; Dorin, J.; Taylor, K.; Barran, P.,Development of an Ion Mobility Quadrupole Time of Flight Mass Spectrometer-The MoQTOF, Anal. Chem. 2008, 80(16), 6336-6344.

 

Kärkkäinen, T.S.; Kartha, K. P. R.; MacMillan D.; Field, R.A.  Iodine-mediated glycosylation en route to mucin-related glyco-aminoacids and glycopeptides, Carbohydrate Res. 2008, 343, 1830-1834.

 

Macmillan, D.; Richardson, J.P.  Mucin-Based Vaccines, Fraser-Reid Ed. Glycoscience, 2008, 2645-2698.

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Taylor, K.; Clarke, D. J.; McCullough, B.; Chin, W.; Seo, E.; Yang, D.; Oppenheim, J.; Uhrin, D.; Govan, J. R. W.; Campopiano, D. J.; MacMillan, D.; Barran, P.; Dorin, J. R., Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of β-Defensin 3. J. Biol. Chem. 2008, 283, (11), 6631-6639.

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Macmillan, D.  Method of covalently linking a carbohydrate or polyalkylene oxide to a peptide, precursors for use in the method and resultant products. PCT Int. Appl. 2008, 102pp. CODEN:PIXXD2; WO2008001109.

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2006

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Macmillan, D. Evolving strategies for protein synthesis converge on native chemical ligation. Angew. Chem. Int Ed. 2006, 45, 7668-7672.

 

Macmillan D.; Blanc, J.  A novel neoglycopeptide linkage compatible with native chemical ligation, Org. Biomol. Chem. 2006, 4(15), 2847-2850.

 

2005

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Bloom, J.D.; Meinhold, P.; Meyer, M.M.; Otey, C.R.; Macmillan, D.; Arnold, F.H.  Evolving Strategies for Enzyme Engineering.  Curr. Opin. Struct. Biol. 2005, 15, 447-452.

 

Shirran, S.; Garnaud, P.; Daff, S.; MacMillan, D.; Barran, P. The formation of a complex between calmodulin and neuronal nitric oxide synthase is determined by ESI-MS. Journal of the Royal Society-Interface, 2005, 2, 465 - 476.

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2004

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Macmillan, D.; Anderson D.W.  Rapid synthesis of acyltransfer auxiliaries for cysteine-free Native Glycopetide Ligation. , 6(25), 4659-4662.

 

Macmillan, D.; Arham, L.  Cyanogen Bromide Cleavage Generates Fragments Suitable for Expressed Protein and Glycoprotein Ligation. J. Am. Chem. Soc. 2004, 124, 9530-9531.

 

Macmillan, D.; Bertozzi, C. R,  Modular Assembly of Glycoproteins: Towards the Synthesis of GlyCAM-1 by using Expressed Protein Ligation. Angew. Chem. Int. Ed.  2004, 43, 1355-1359.

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2003

 

Macmillan, D.; Daines, A. M.  Recent developments in the synthesis and discovery of oligosaccharides and glycoconjugates for the treatment of disease. Curr. Med, Chem. 2003, 10, 2733-2773.

 

2002

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Macmillan, D.; Daines, A. M.; Bayrhuber, M.; Flitsch, S. L.  Solid-Phase Synthesis of Thioether-Linked Glycopeptide Mimics for Application to Glycoprotein Semi-synthesis. Org. Lett. 2002, 4, 1467-1470.

 

2001

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Macmillan, D., Bill, R. M., Sage, K. A., Fern, D. & Flitsch, S. L.  Selective in vitro glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin. Chem. Biol. 2001, 8, 133-145.

 

2000

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Macmillan, D. & Bertozzi, C. R. New directions in glycoprotein engineering. Tetrahedon, 2000, 56, 9515-9525.